IDH1 (R132H)

Isocitrate dehydrogenase assay, Diaphorase/Resazurin-coupled assay
CAT#
IDH1 (R132H)
Enzyme
Human IDH1 (R132H) mutant
Synonym
Isocitrate dehydrogenase [NADP] cytoplasmic (EC:1.1.1.42), NADP(+)-specific ICDH, Oxalosuccinate decarboxylase)
Substrate
1.5 mM α-ketoglutarate, 15 µM NADPH
Reaction
aKG + NADPH = 2HG + NADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
AGI-51983.4
IDH-C2277.5
AG-1202.8
Scientific Information
O75874 (http://www.expasy.org/uniprot/O75874)
Screening Location
Malvern, USA
Reference compound IC50 for IDH1 (R132H)
Reference compound IC50 for IDH1 (R132H)