IDH1 WT

Isocitrate dehydrogenase assay, Diaphorase/Resazurin-coupled assay
CAT#
IDH1 WT
Enzyme
Human IDH1 wild type
Synonym
Isocitrate dehydrogenase [NADP] cytoplasmic (EC:1.1.1.42), NADP(+)-specific ICDH, Oxalosuccinate decarboxylase)
Substrate
65 µM isocitrate, 50 µM NADP
Reaction
Isocitrate + NADP = aKG + NADPH
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
AGI-5198>20000
IDH-C227>20000
Scientific Information
O75874 (http://www.uniprot.org/uniprot/O75874 )
Screening Location
Malvern, USA
Reference compound inhibition of IDH1 WT
Reference compound inhibition of IDH1 WT