IDH2 (R140K)

Isocitrate dehydrogenase assay, Diaphorase/Resazurin-coupled assay
CAT#
IDH2 (R140K)
Enzyme
Human IDH2 (R140K) mutant
Synonym
Isocitrate dehydrogenase [NADP], mitochondrial, ICD-M, Oxalosuccinate decarboxylase)
Substrate
5 mM α-ketoglutarate, 15 µM NADPH
Reaction
aKG + NADPH = 2HG + NADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundIC50 (nM)
IDH2-C1005.0
AG-22144
AGI-67803.6
Scientific Information
P48735 (http://www.expasy.org/uniprot/P48735)
Screening Location
Malvern, USA
Reference compound IC50 for IDH2 (R140K)
Reference compound IC50 for IDH2 (R140K)