IDH2 (R172Q)

Isocitrate dehydrogenase assay, Diaphorase/Resazurin-coupled assay
CAT#
IDH2 (R172Q)
Enzyme
Human IDH2 (R172Q) mutant
Synonym
Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42); ICD-M; Oxalosuccinate decarboxylase
Substrate
50 µM α-ketoglutarate, 15 µM NADPH
Reaction
aKG + NADPH = 2HG + NADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundIC50 (nM)
IDH2-C10083
AG-22119
AGI-678010
Scientific Information
P48735 (http://www.expasy.org/uniprot/P48735)
Screening Location
Malvern, USA
Reference compound IC50 for IDH2 (R172Q)
Reference compound IC50 for IDH2 (R172Q)