JAK1 JH2 Domain Binding Assay for compound screening and profiling via Probe-Displacement HTRF-based detection.
Target Overview
CAT#
JAK1 JH2
Enzyme
Human JAK1 JH2 (aa 561-860)
Probe
JAK2 JH2 Tracer
Scientific Information
P23458 (http://www.uniprot.org/uniprot/P23458)
Assay Properties
Reaction
JAK1 JH2 + tracer = HTRF signal
Readout
Probe competition
Reference Compound IC50s
| Compound | IC50 (nM) |
|---|---|
| BMS-986165 | 5.8 |
| JNJ-7706621 | 26 |
| Zasocitinib | >25000 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinase Assays
Reference compound IC50 for JAK1 JH2
