Activity-based KAT5 Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.
CAT#
KAT5
Enzyme
Human KAT5
Synonyms
Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, HTATIP, TIP60
Substrates
Histone H2A, 5 μM
Acetyl CoA, 3 μM
Acetyl CoA, 3 μM
Reaction
[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Anacardic Acid | 30,000 |
| Garcinol | 11,000 |
| Curcumin | 25,000 |
Scientific Information
Q92993 (http://www.uniprot.org/uniprot/Q92993)
Screening Location
Malvern, USA
Reference Compound IC50 for KAT5
