KAT6A Histone Acetyltransferase Assay Service

Activity-based KAT6A Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.

Target Overview

CAT#

KAT6A

Enzyme

Human KAT6A

Synonyms

Histone acetyltransferase KAT6A, MOZ, MYST3, RUNXBP2, ZNF220

Substrates

Histone H3, 5 μM
Acetyl CoA, 0.5 μM

Assay Properties

Reaction

[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Anacardic Acid 40,000
Garcinol 31,000
Curcumin >100,000
C646 13,000

Scientific Information

Q92794 (https://www.uniprot.org/uniprotkb/Q92794/)

Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Histone Acetyltransferase Assay (HAT) Services for Drug Discovery

Reference Compound IC50 for KAT6A

Reference Compound IC50 for KAT6A