LATS1 Kinase Assay Service

Activity-based LATS1 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
LATS1
Enzyme
Human LATS1
HGNC
LATS1
Synonym
WARTS, wts
Substrates
Peptide substrate, [KKRNRRLSVA], 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine3.5
Ro 31-822010
GW 507414,000
H-89500
Rottlerin>50,000
Scientific Information
O95835 (http://www.uniprot.org/uniprot/Q95835)
Screening Location
Malvern, USA
Reference compound IC50 for LATS1
Reference compound IC50 for LATS1