LRRK2 R1441C Kinase Activity Assay Service

Activity-based LRRK2 R1441C kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

LRRK2 R1441C

Enzyme

Human LRRK2 R1441C, mutant

HGNC

LRRK2 (R1441C)

Manning ID

LRRK2

Synonym

PARK8, ROCO2, FLJ45829, DKFZp434H2111, LRRK2, LRRK2 R1441C, LRRK2 (R1441C)

UniProt

Q5S007 (LRRK2_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TKL

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RBER-CHKtide, ATP

Reaction

RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 2
Sorafenib 6700
Sunitinb 150

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice LRRK2 R1441C
345 wt Profiler No
345 IC50 wt Profiler No
Mutant Profiler Addon Yes
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

No

Product Number N/A
Web Shop Reaction Biology Online Shop