LYN Kinase Assay Service

Activity-based LYN kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
LYN

Enzyme
Human LYN

HGNC
LYN

Synonym
JTK8

Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 0.8
PP2 46
AG1478 260
D-64406 630
Scientific Information
P07948 (http://www.uniprot.org/uniprot/P07948)

Screening Location
Malvern, USA

Reference compound IC50 for LYN
Reference compound IC50 for LYN

PDF