Activity-based MINK1 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
MINK1
Enzyme
Human MINK1, wt
HGNC
MINK1
Manning ID
ZC3/MINK
Synonym
B55, MAP4K6, MGC21111, MINK, ZC3, hMINK, hMINKbeta, MINK1, YSK2, MINK/MINK1
UniProt
Q8N4C8 (MINK1_HUMAN)
Kinase Type
Protein kinase
Kinase Group
STE
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-CHKtide, ATP
Reaction
RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 5 |
| Sorafenib | 1500 |
| Sunitinb | 85 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | MINK1 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – MINK1 |
| Product Number |
0698-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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