MNK2 Kinase Assay Service

Activity-based MNK2 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
MNK2
Enzyme
Human MNK2
HGNC
MKNK2
Synonym
MNK2
Substrates
MBP (Myelin Basic Protein), 10 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine15.5
Ro 31-822014,600
GW 50743,700
H-8919,300
Rottlerin20,000
Scientific Information
Q9HBH9 (http://www.uniprot.org/uniprot/Q9HBH9)
Screening Location
Malvern, USA
Reference compound IC50 for MNK2/MKNK2
Reference compound IC50 for MNK2/MKNK2