MTOR Kinase Activity Assay Service

Activity-based MTOR kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

MTOR

Enzyme

Human MTOR, wt

HGNC

MTOR

Manning ID

FRAP

Synonym

FRAP,  FRAP2,  MTOR,  RAFT1,  RAPT1, mTOR/FRAP1, FRAP1, FRAP2, RAFT1, RAPT1, rapamycin target protein, MTOR, mTOR

UniProt

P42345 (MTOR_HUMAN)

Kinase Type

Protein kinase

Kinase Group

Atypical

Assay Properties

Assay Format

33PanQinaseTM

Substrates

Casein, ATP

Reaction

Casein + 33P-ATP = 33P-Casein + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
PI-103 35
Sorafenib 10000
Sunitinb 100000

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice MTOR
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

No

Product Number

N/A

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