MUSK Kinase Assay Service

Activity-based MUSK kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
MUSK
Enzyme
Human MUSK
HGNC
MUSK
Synonym
MUSK
Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine2.2
PP2>100,000
AG14789,200
EGFR/Erb Inhibitor>100,000
D-64406560
Scientific Information
O15146 (http://www.uniprot.org/uniprot/O15146)
Screening Location
Malvern, USA
Reference compound IC50 for MUSK
Reference compound IC50 for MUSK