MUSK Kinase Assay Service

Activity-based MUSK kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
MUSK

Enzyme
Human MUSK

HGNC
MUSK

Synonym
MUSK

Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 2.2
PP2 >100,000
AG1478 9,200
EGFR/Erb Inhibitor >100,000
D-64406 560
Scientific Information
O15146 (http://www.uniprot.org/uniprot/O15146)

Screening Location
Malvern, USA

Reference compound IC50 for MUSK
Reference compound IC50 for MUSK