MYLK2 Kinase Activity Assay Service

Activity-based MYLK2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

MYLK2

Enzyme

Human MYLK2, wt

HGNC

MYLK2

Manning ID

skMLCK

Synonym

KMLC, MLCK, MYLK2, skMLCK, MLCK2, MLCK2/MYLK2

UniProt

Q9H1R3 (MYLK2_HUMAN)

Kinase Type

Protein kinase

Kinase Group

CAMK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RB-S6P, ATP

Reaction

RB-S6P + 33P-ATP = 33P-RB-S6P + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 107
Sorafenib 4800
Sunitinb 50

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice MYLK2
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – MYLK2
(Activity verified by 33PanQinaseTM-Assay)

Product Number

0445-0000-1

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