KAT7/MYST2 Histone Acetyltransferase Assay Service

Activity-based KAT7/MYST2 Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.

Target Overview

CAT#

KAT7/MYST2

Enzyme

Human KAT7/MYST2

Synonyms

Histone acetyltransferase MYST2, Histone acetyltransferase binding to ORC1 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, HBO1, HBOa

Substrates

Histone H3, 2.5 μM
Acetyl CoA, 0.5 μM

Assay Properties

Reaction

[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Anacardic Acid 5,200
Garcinol 11,000
Curcumin 44,000
C646 15,000

Scientific Information

O95251 (http://www.uniprot.org/uniprot/O95251)

Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Histone Acetyltransferase Assay (HAT) Services for Drug Discovery

Reference Compound IC50 for KAT7/MYST2

Reference Compound IC50 for KAT7/MYST2