NQO2 (Ribosyldihydronicotinamide dehydrogenase [quinone]) assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
NQO2
Enzyme
Human NQO2
Synonyms
NMOR2, NRH dehydrogenase [quinone] 2
Scientific Information
Assay Properties
Substrate
Menadione, dihydrobenzylnicotinamide (BNAH)
Reaction
1-Benzyl-1,4-dihydronicotinamide + menadione = 1-Benzyl-nicotinamide + menadiol
BNAH fluorescence, kinetic measurement
Readout
Enzymatic activity
Reference Compound IC50s
Compounds | IC50 (nM) |
---|---|
Imatinib mesylate | 183 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website NAD(P)H Dehydrogenase Assays (NQO)
Reference compound inhibition of NQO2

PDF