OSR1/OXSR1 Kinase Assay Service

Activity-based OSR1/OXSR1 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
OSR1/OXSR1

Enzyme
Human OSR1/OXSR1

HGNC
OXSR1

Synonym
OSR1, KIAA1101

Substrates
Peptide substrate, [RRHYYYDTHTNTYYLRTFGHNTRR], 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 91
Ro 31-8220 26,900
GW 5074 13,700
Rottlerin 5,800
Scientific Information
O95747 (http://www.uniprot.org/uniprot/O95747)

Screening Location
Malvern, USA

Reference compound IC50 for OSR1/OXSR1
Reference compound IC50 for OSR1/OXSR1

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