Activity-based PI3KC2G/PIK3C2G lipid kinase assay for compound screening and profiling via ADP-Glo kinase assay.
Target Overview
CAT#
PI3KC2G/PIK3C2G
Enzyme
Human PI3KC2G/PIK3C2G
HGNC
PIK3C2G
Synonym
PI3K-C2GAMMA, PI3K-C2-gamma
Scientific Information
B7ZLY6 (http://www.uniprot.org/uniprot/B7ZLY6)
Assay Properties
Substrates
PI:PS, 10 µM
ATP, 10 µM
ATP, 10 µM
Reaction
1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 |
|---|---|
| PI-103 | 8.2 nM |
| PIK-93 | 3.8 nM |
| GSK-A1 | 2.3 nM |
| KU-55933 | 5.3 µM |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinase Assays
Reference compound inhibition of PI3KC2G/PIK3C2G
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