PIK3CB E633K/PIK3R1 Kinase Activity Assay Service

Activity-based PIK3CB E633K/PIK3R1 kinase assay for compound screening and profiling via ADP-Glo – assay technology

Target Overview

RBE Target ID

PIK3CB E633K/PIK3R1

Enzyme

Human PIK3CB E633K/PIK3R1, mutant

HGNC

PIK3CB (E633K)-PIK3R1

Manning ID

N/A

Synonym

PIK3CB, P110BETA, PI3K, PI3KBETA, PI3K-beta, PIK3C1, PIK3CB E633K/PIK3R1

UniProt

P42338 (PK3CB_HUMAN)

Kinase Type

Lipid kinase

Kinase Group

PI3K

Assay Properties

Assay Format

ADP-Glo

Substrates

PIP2:PS, ATP

Reaction

PIP2:PS + ATP = P-PIP2:PS + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Wortmannin 310
LY294002 2600
PI-103 140

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice PIK3CB E633K/PIK3R1
345 wt Profiler No
345 IC50 wt Profiler No
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – PIK3CB E633K/PIK3R1
(Activity verified by ADP-Glo – Assay)

Product Number

1531-1165-1

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