PIK3CD/PIK3R1 Kinase Activity Assay Service

Activity-based PIK3CD/PIK3R1 kinase assay for compound screening and profiling via ADP-Glo – assay technology

Target Overview

RBE Target ID

PIK3CD/PIK3R1

Enzyme

Human PIK3CD/PIK3R1, wt

HGNC

PIK3CD-PIK3R1

Manning ID

N/A

Synonym

p110D, P110DELTA, PI3K, PI3K-delta, p110-delta, PIK3CD, PIK3CD/PIK3R1, PI3Kd (p110d/p85a)

UniProt

O00329 (PK3CD_HUMAN)

Kinase Type

Lipid kinase

Kinase Group

PI3K

Assay Properties

Assay Format

ADP-Glo

Substrates

PIP2:PS, ATP

Reaction

PIP2:PS + ATP = P-PIP2:PS + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Wortmannin 9
LY294002 1800
PI-103 36

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice PIK3CD/PIK3R1
345 wt Profiler No
345 IC50 wt Profiler No
Mutant Profiler Addon No
Lipid Kinase Profiler Addon Yes
IC50 Profiler IC50 Lipid Kinase Profiler
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – PIK3CD/PIK3R1
(Activity verified by ADP-Glo – Assay)

Product Number

1162-1165-1

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