Activity-based PIP4K2C kinase assay for compound screening and profiling via ADP-Glo – assay technology
Target Overview
RBE Target ID
PIP4K2C
Enzyme
Human PIP4K2C, wt
HGNC
PIP4K2C
Manning ID
N/A
Synonym
PIP4KII-gamma, PIP5K2C
UniProt
Q8TBX8 (PI42C_HUMAN)
Kinase Type
Lipid kinase
Kinase Group
PIP5K
Assay Properties
Assay Format
ADP-Glo
Substrates
PI(5)P/PS, ATP
Reaction
Substrate + ATP = P-Substrate + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Wortmannin | >10000 |
| PI-103 | >10000 |
| LY294002 | >10000 |
| BAY-091 | 2000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | PIP4K2C |
| wt Profiler | No |
| IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | Yes |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | No |
| Product Number | N/A |
| Web Shop | Reaction Biology Online Shop |
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