PKD2 (G870E) Kinase Assay Service

Activity-based PKD2 (G870E) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
PKD2 (G870E)
Enzyme
Human PKD2 (G870E)
HGNC
PRKD2 (G870E)
Synonym
PKD2, HSPC187
Substrates
Peptide substrate, [KKLNRTLSVA], 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine1.0
Ro 31-8220350
GW507411,000
H-891,600
Rottlerin7,500
Scientific Information
Q9BZL6 (http://www.uniprot.org/uniprot/Q9BZL6)
Screening Location
Malvern, USA
Reference compound IC50 for PKD2 (G870E)
Reference compound IC50 for PKD2 (G870E)