PPAC (ACP1/LMW-PTP-A) Phosphatase Assay Service

PPAC (ACP1/LMW-PTP-A) Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.

Target Overview

CAT#

PPAC (ACP1/LMW-PTP-A)

Enzyme

Human PPAC (ACP1/LMW-PTP-A), isoform A

Synonyms

Low molecular weight phosphotyrosine protein phosphatase, Adipocyte acid phosphatase, Low molecular weight cytosolic acid phosphatase, Red cell acid phosphatase 1, LMPTP-A, HCPTP-A

Substrates

Fluorogenic substrate DiFMUP, 10 μM

Assay Properties

Reaction

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50 (μM)
PTP1B Inhibitor 7.4
LMWPTP Inhibitor-1 3

Scientific Information

P24666 (P24666-1) (http://www.uniprot.org/uniprot/P24666)

Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Phosphatase Assay Services for Drug Discovery

Reference Compound IC50 for PPAC (ACP1/LMW-PTP-A)

Reference Compound IC50 for PPAC (ACP1/LMW-PTP-A)