PTPN12/PTP-PEST Phosphatase Assay Service

PTPN12/PTP-PEST Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPN12/PTP-PEST
Enzyme
Human PTPN12/PTP-PEST
Synonyms
Tyrosine-protein phosphatase non-receptor type 12, Protein-tyrosine phosphatase G1, PTN12
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
NSC-87877630
PHPS1110
PTP1B Inhibitor3,300
Scientific Information
Q05209 (http://www.uniprot.org/uniprot/Q05209)
Screening Location
Malvern, USA
Reference Compound IC50 for PTPN12/PTP-PEST
Reference Compound IC50 for PTPN12/PTP-PEST