PTPN1/PTP1B Phosphatase Assay Service

PTPN1/PTP1B Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPN1/PTP1B
Enzyme
Human PTPN1/ PTP1B
Synonyms
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
NSC-87877650
PHPS1430
PTP1B Inhibitor9,400
Scientific Information
P18031 (http://www.uniprot.org/uniprot/P18031)
Screening Location
Malvern, USA
Reference Compound IC50 for PTPN1/PTP1B
Reference Compound IC50 for PTPN1/PTP1B