PTPN2/TC-PTP Phosphatase Assay Service

PTPN2/TC-PTP Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPN2/TC-PTP
Enzyme
Human PTPN2/TC-PTP
Synonyms
Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, PTN2, PTPT
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
NSC-878774,200
PHPS1170
PTP1B Inhibitor11,000
Scientific Information
P17706 (http://www.uniprot.org/uniprot/P17706)
Screening Location
Malvern, USA
Compound IC50 Data for PTPN2/TC-PTP
Compound IC50 Data for PTPN2/TC-PTP