PTPN7/LC-PTP Phosphatase Assay Service

PTPN7/LC-PTP Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview

CAT#
PTPN7/LC-PTP

Enzyme
Human PTPN7/LC-PTP

Synonyms
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, PTN7

Substrates
Fluorogenic substrate DiFMUP, 10 μM

Assay Properties

Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
NSC-87877 1,700
PHPS1 97
PTP1B Inhibitor 7,000
Scientific Information
P35236 (http://www.uniprot.org/uniprot/P35236)

Screening Location
Malvern, USA

Reference Compound IC50 for PTPN7/LC-PTP
Reference Compound IC50 for PTPN7/LC-PTP