PTPN7/LC-PTP Phosphatase Assay Service

PTPN7/LC-PTP Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPN7/LC-PTP
Enzyme
Human PTPN7/LC-PTP
Synonyms
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, PTN7
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
NSC-878771,700
PHPS197
PTP1B Inhibitor7,000
Scientific Information
P35236 (http://www.uniprot.org/uniprot/P35236)
Screening Location
Malvern, USA
Reference Compound IC50 for PTPN7/LC-PTP
Reference Compound IC50 for PTPN7/LC-PTP