PTPRB Phosphatase Assay Service

PTPRB Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.

Target Overview

CAT#

PTPRB

Enzyme

Human PTPRB

Synonyms

Receptor-type tyrosine-protein phosphatase beta, Protein-tyrosine phosphatase beta, Vascular endothelial protein tyrosine phosphatase, VE-PTP

Substrates

Fluorogenic substrate DiFMUP, 10 μM

Assay Properties

Reaction

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50 (μM)
PTP1B Inhibitor 5.3
NSC87877 9.1
PHPS1 99

Scientific Information

P23467 (https://www.uniprot.org/uniprotkb/P23467)

Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Phosphatase Assay Services for Drug Discovery

Reference Compound IC50 for PTPRB

Reference Compound IC50 for PTPRB