RET Y791F Kinase Activity Assay Service

Activity-based RET Y791F kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

RET Y791F

Enzyme

Human RET Y791F, mutant

HGNC

RET (Y791F)

Manning ID

RET

Synonym

RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1, RET Y791F, RET (Y791F)

UniProt

P07949 (RET_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY+ 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 8
Sorafenib 120
Sunitinb 64

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice RET Y791F
345 wt Profiler No
345 IC50 wt Profiler No
Mutant Profiler Addon Yes
Lipid Kinase Profiler Addon No
IC50 Profiler IC50 RET Profiler
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – RET Y791F
(Activity verified by 33PanQinaseTM-Assay)

Product Number

1094-0000-1

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