RET Y806H Kinase Activity Assay Service

Activity-based RET Y806H kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

RET Y806H

Enzyme

Human RET Y806H, mutant

HGNC

RET (Y806H)

Manning ID

RET

Synonym

RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1, RET Y806H, RET (Y806H)

UniProt

P07949 (RET_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties

Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY+ 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 42
Sorafenib 870
Sunitinb 570

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice RET Y806H
345 wt Profiler No
345 IC50 wt Profiler No
Mutant Profiler Addon Yes
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

Yes; ProQinaseTM – RET Y806H
(Activity verified by 33PanQinaseTM-Assay)

Product Number

1378-0000-1

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