Activity-based RIPK1 kinase assay for compound screening and profiling via ADP-Glo kinase assay.
Target Overview
CAT#
RIPK1 (ADP-Glo)
Enzyme
Human RIPK1
HGNC
RIPK1
Synonym
RIP1, RIP
Assay Properties
Substrates
ATP, 10 µM
Reaction
ATP = ADP + Pi
Readout
ADP-Glo Detection
Reference Compound IC50s
| Compounds | IC50 |
|---|---|
| GSK2982772 | 10.2 nM |
| Staurosporine | 61.9 nM |
Scientific Information
Q13546 (http://www.uniprot.org/uniprot/Q13546)
Screening Location
Malvern, PA, USA
Reference compound inhibition for RIPK1
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