ROS1 (G2032R) Kinase Assay Service

Activity-based ROS1 (G2032R) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
ROS1 (G2032R)

Enzyme
Human ROS1 (G2032R)

HGNC
ROS1 (G2032R)

Synonym
ROS, MCF3

Substrates
Peptide substrate, [KKKSPGEYVNIEFG], 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 10
PP2 2,100
AG1478 17,000
PDGFR I-III 45,000
D-64406 >100,000
Scientific Information
P08922 (http://www.uniprot.org/uniprot/P08922)

Screening Location
Malvern, USA

Reference compound IC50 for ROS1 (G2032R)
Reference compound IC50 for ROS1 (G2032R)