RPS6KA4 Kinase Activity Assay Service

Activity-based RPS6KA4 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview

RBE Target ID

RPS6KA4

Enzyme

Human RPS6KA4, wt

HGNC

RPS6KA4

Manning ID

MSK2

Synonym

RSK-B, MSK2, RPS6KA4, MSK2/RPS6KA4

UniProt

O75676 (KS6A4_HUMAN)

Kinase Type

Protein kinase

Kinase Group

AGC

Assay Properties

Assay Format

33PanQinaseTM

Substrates

RBER-CHKtide, ATP

Reaction

RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 57
Sorafenib 10000
Sunitinb 2300

Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability

Screening Opportunities
FreeChoice RPS6KA4
345 wt Profiler Yes
345 IC50 wt Profiler Yes
Mutant Profiler Addon No
Lipid Kinase Profiler Addon No
IC50 Profiler No
Recombinant Protein Availability
Active recombinant protein

No

Product Number

N/A

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