KRAS-related Assays: SOS2 binding assay service for compound screening and profiling using the thermal shift assay format to measure compound binding to the target
SOS2 (aa 562-1047), strep tagged. Expressed in Ecoli.
Son of sevenless homolog 2
SOS2: Q07890 (https://www.uniprot.org/uniprot/Q07890)
Malvern, PA, US
Compound binding to SOS2
Protein stability change due to ligand binding via thermal shift assay
Typically tested at 0.1 mg/ml
No reference compound is currently available for SOS2. No protein stabilization was observed when tested with reference compounds BAY293, ARS-1620, AMG-510 or BI-2852.
Melt peak of SOS2 protein at increasing temperatures in presence of compounds BAY-293 (pink), ARS-1620 (green), AMG-510 (blue) or BI-2852 (brown) or none (black)