SP140 Bromodomain Assay Service (AlphaScreen)

SP140-His Reader Domain Assay for compound screening and profiling using the AlphaScreen assay format to measure compound binding to the target.

Target Overview
CAT#

SP140-His

Enzyme

Human SP140-His

Synonyms

Nuclear body protein SP140, Lymphoid-restricted homolog of Sp100, LYSP100

Substrates

Histone H3 peptide (1-21) K9/14Ac

Assay Properties
Reaction

AlphaScreen Binding assay

Readout

Fluorescence

Reference Compound IC50s
Compounds IC50 (nM)
JQ-1 63,000
SGC-CBP30 52,000
Scientific Information

Q13342 (http://www.uniprot.org/uniprot/Q13342)

Screening Location

Malvern, USA

Further information

More information can be found on our website Reader Domain Assay Services.

Reference Compound IC50 for SP140

Reference Compound IC50 for SP140