SP140-His Reader Domain Assay for compound screening and profiling using the thermoshift assay format to measure compound binding to the target.
Human SP140 bromodomain, His-tagged
Lymphoid-restricted homolog of Sp100; Nuclear autoantigen Sp-140; Speckled 140 kDa
Thermal stability change after ligand binding
0.1 mg/ml (4.2 µM)
PFI1 - 2 (Grey)CBP112 - 2 (Purple)Bromosporine - 1.5 (Blue)No stabilization was observed in the presence of other control compounds (JQ1, SGC-CBP30, BET151, RVX-208, GSK2801 and PFI3)
More information can be found on our website Reader Domain Assay Services.