TACE Protease Assay Service

TACE Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
TACE
Enzyme
TACE, human recombinant (residues 1-671) expressed in insect cell with His tag
Synonym
A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen
Substrates
(5-FAM/QXLTM) FRET peptide
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (M)
NNGH6.88E-07
Actinonin1.14E-06
GM60013.03E-08
MMP Inhibitor III2.22E-08
MMP-9/MMP-13 Inhibitor I1.99E-09
Scientific Information
P78536 (http://www.uniprot.org/uniprot/P78536)
Screening Location
Malvern, USA
Reference compound IC50 for TACE
Reference compound IC50 for TACE