TGFBR2 Kinase Assay Service

Activity-based TGFBR2 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
TGFβR2
Enzyme
Human TGFβR2
HGNC
TGFBR2
Synonym
HNPCC6, MFS2, RIIC, TGFbeta-RII
Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine23,000
Ro 31-8220>10,000
GW 50748,300
LDN19318990
Rottlerin34,000
Scientific Information
P37173 (http://www.uniprot.org/uniprot/P37173)
Screening Location
Malvern, USA
Reference compound IC50 for TGFβR2
Reference compound IC50 for TGFβR2