TIE2 (Y1108F) Kinase Assay Service

Activity-based TIE2 (Y1108F) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
TIE2 (Y1108F)

Enzyme
Human TIE2 (Y1108F)

HGNC
TEK (Y1108F)

Synonym
VMCM, TIE-2, VMCM1, CD202B

Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Scientific Information
Q02763 (http://www.uniprot.org/uniprot/Q02763)

Screening Location
Malvern, USA

Reference compound IC50 for TIE2 (Y1108F)