TRKC (G623E) Kinase Assay Service

Activity-based TRKC (G623E) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
TRKC (G623E)
Enzyme
Human TRKC (G623E)
HGNC
NTRK3 (G623E)
Synonym
GP145-TrkC
Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine15
PP26,400
AG1478>100,000
EGFR/ErbB Inhibitor>100,000
D-64406>100,500
Scientific Information
Q16288 (http://www.uniprot.org/uniprot/Q16288)
Screening Location
Malvern, USA
Reference compound IC50 for TRKC (G623E)
Reference compound IC50 for TRKC (G623E)