TRKC Kinase Mutant Profiler Service

Activity-based TRKC mutant kinase panel for compound profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#

TRKC

Enzyme

Human TRKC

HGNC

NTRK3

Synonym

NT-3 growth factor receptor [Precursor], Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, NTRK3

Assay Properties
Reaction

Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s (nM)
Mutant Staurosporine PP2 AG1478 PDGFR I-III EGFR/ErbB Inhibitor D-64406
WT <0.1 3,000 3,800 6,900 n.a. 321
G623E 15 6,400 >100,000 n.a. >100,000 >100,500
G623R 19 49,100 >100,000 n.a. >100,000 >100,000
G623R/L686M 113 >100,000 >100,000 n.a. >100,000 38,000
L686M 11 22,000 >100,000 n.a. >100,000 2,600
G696A 0.9 9,800 14,000 n.a. >100,000 220
Screening Location

Malvern, USA