TRKC (L686M) Kinase Assay Service

Activity-based TRKC (L686M) kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
TRKC (L686M)

Enzyme
Human TRKC (L686M)

HGNC
NTRK3 (L686M)

Synonym
GP145-TrkC

Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Scientific Information
Q16288 (http://www.uniprot.org/uniprot/Q16288)

Screening Location
Malvern, USA

Reference compound IC50 for TRKC (L686M)