TTBK1 Kinase Assay Service

Activity-based TTBK1 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
TTBK1
Enzyme
Human TTBK1
HGNC
TTBK1
Synonym
KIAA1855, BDTK
Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine>100,000
Ro 31-8220>100,000
GW 5074>100,000
H-89>100,000
SB20219018,800
Scientific Information
Q5TCY1 (http://www.uniprot.org/uniprot/Q5TCY1)
Screening Location
Malvern, USA
Reference compound IC50 for TTBK1
Reference compound IC50 for TTBK1