TTK Kinase Assay Service

Activity-based TTK kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
TTK

Enzyme
Human TTK

HGNC
TTK

Synonym
ESK, MPS1L1, MPS1, PYT

Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Scientific Information
P33981 (http://www.uniprot.org/uniprot/P33981)

Screening Location
Malvern, USA

Reference compound IC50 for TTK