TYK2 JH2 Domain Binding Assay for compound screening and profiling via probe displacement, HTRF-based detection.
Target Overview
CAT#
TYK2 JH2
Enzyme
Human TYK JH2 (aa 575-869)
Probe
JAK2 JH2 Tracer
Scientific Information
P29597 (http://www.uniprot.org/uniprot/P29597)
Assay Properties
Reaction
TYK2 JH2 + tracer = HTRF signal
Readout
Probe competition
Reference Compound IC50s
| Compound | IC50 (nM) |
|---|---|
| BMS-986165 | 0.24 |
| JNJ-7706621 | 89 |
| Zasocitinib | 0.26 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinase Assays
Reference compound IC50 for TYK2 JH2
