TYRO3/SKY Kinase Assay Service

Activity-based TYRO3/SKY kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
TYRO3/SKY

Enzyme
Human TYRO3/SKY

HGNC
TYRO3

Synonym
BYK, Brt, Dtk, Sky, Tif

Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Scientific Information
Q06418 (http://www.uniprot.org/uniprot/Q06418)

Screening Location
Malvern, USA

Reference compound IC50 for TYRO3/SKY