YSK4/MAP3K19 Kinase Assay Service

Activity-based YSK4/MAP3K19 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
YSK4/MAP3K19
Enzyme
Human YSK4/MAP3K19
HGNC
MAP3K19
Synonym
M3K19, RCK, YSK4
Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (nM)
Staurosporine28
Ro 31-82202,000
GW5074340
H-8935,000
Rottlerin>100,000
Scientific Information
Q56UN5 (http://www.uniprot.org/uniprot/Q56UN5)
Screening Location
Malvern, USA
Reference compound IC50 for YSK4/MAP3K19
Reference compound IC50 for YSK4/MAP3K19