Activity-based ARH3 (ADP-ribosylhydrolase) assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
ARH3
Enzyme
Human ARH3
Synonym
ADPRS, ADPRHL2
Scientific Information
Q9NX46 (http://www.uniprot.org/uniprot/Q9NX46)
Assay Properties
Substrate
TFMU-ADPr
Reaction
TFMU-ADPr = TFMU + ADPr
TFMU fluorescence, kinetic measurement
Readout
Enzymatic activity
Reference Compound IC50s
Compounds | IC50 |
---|---|
PDD 00017273 | >100 µM |
ADP-HPD | 529 nM |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Poly (ADP-ribose) Polymerase (PARP) Assay Services
Reference compound inhibition for ARH3
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