ARH3 Assay Service

Activity-based ARH3 (ADP-ribosylhydrolase) assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.

Target Overview
CAT#

ARH3

Enzyme

Human ARH3

Synonym

ADPRS, ADPRHL2

Scientific Information

Q9NX46 (http://www.uniprot.org/uniprot/Q9NX46)

Assay Properties
Substrate

TFMU-ADPr

Reaction

TFMU-ADPr = TFMU + ADPr
TFMU fluorescence, kinetic measurement

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50
PDD 00017273 >100 µM
ADP-HPD 529 nM
Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Poly (ADP-ribose) Polymerase (PARP) Assay Services

Reference compound inhibition for ARH3

Reference compound inhibition for ARH3