Surface Plasmon Resonance (SPR) technique for evaluating direct binding of small molecule inhibitors to BCL-2 and mutants F104L, D103Y, and G101V
BCL-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator
Produced at Reaction Biology
Malvern, PA, USA
More information can be found on our website SPR Assay Services for Drug Discovery
Binding kinetics of ABT-737 to BCL-2 wildtype and mutants F104L, D103Y, and G101V
The data was collected on a Biacore 8K using single-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model.